Situated in the heart of the area known as Madrid de los Austrias, this neoclassical inspired building was built to house Spain's Royal Academy of Medicine by architect Luis María Cabello Lapiedra between 1910 and 1913.

The building is spread over three floors, and the assembly hall was based on the amphitheatre of the London School of Medicine, taking into account the acoustic, optical and lighting conditions. It stands on the site formerly occupied by the National Library.

Its facilities include a library specialised in 18th and 19th century collections, which is the most complete to date in order to perform retrospective searches. Apart from the monographs, it has a collection of 1,041 journals no longer open to new publications, as well as approximately 200 working journals, acquired through interchange with the Annals of the Royal National Academy of Medicine, as well as theses, final dissertations and medical research papers which have been presented to the many awards that the Academy calls each year.  It also houses conference minutes, reference books, offprints, etc, which round of its printed bibliographic collection.

Special mention should be given to the Archive, which has been continuously expanded over the years.

Another important space is the Infanta Margarita Medicine Museum, founded in 2012, which contributes to the preservation, upkeep and enhancement of the documentary and instrumental heritage of Medical Science in Spain, through temporary exhibitions and conferences.