Located in the Literary Quarter in the Lavapiés neighbourhood, the origins of the Oratory date back to 1607, when the Congregation of the Unworthy Slaves of the Blessed Sacrament was set up in Madrid, to which famous figures, such as Lope de Vega, Miguel de Cervantes, Quevedo or Calderón de la Barca belonged. The original oratory was built in 1647, which was knocked down in 1910, when it was rebuilt under Enrique María Repullés.

The church boasts a classicist line in brick. It has a basilica layout and is divided into three naves, of which the central one is twice as wide, a prominent transept and a flat choir. The central nave is covered by a barrel vault and the wings with edges. A dome rises up above the transept.