The first record of this shop is a request for an opening license dated August 18th, 1897. It was submitted by Pedro Canalejo Hernández for the pharmacy he had just purchased for ten thousand pesetas, at Calle Mayor 23. The business had been previously owned by Manuel Rodríguez Hernández, who had opened the store in 1870.

Pedro Canalejo kept the pharmacy until 1902, when he sold it to Francisco Orozco y Cremades. The next owner, in 1911, was Eugenio Piñerua Álvarez, a professor of chemistry at the Universidad Central and author of various volumes on the subject. Finally, in 1921, the Mateo family purchased the business, which remained in their hands for over sixty years. Currently, Teresa Guijarro is in charge of this centrallylocated pharmacy, which offers beauty products, over-the-counter items and medicines.