Little is known about its history; its founder was likely Salvador Roa y Abela, and in 1887 the business was passed to Mariano Passapera Campdera, a pharmacist and full member of the Royal Academy of Natural History. In 1943, Dolores Soriano purchased the store from the widow of Rovas Hoder. Finally, in 1981, the current pharmacist, Ángeles Jiménez Guerra, acquired the establishment.

The business has contributed to the field of Spanish pharmacy through the creation of its famous preparations to treat chilblains. At the beginning of the 20th century, it also sold a remedy for rheumatism for five pesetas, known as Frilax. Illustrious characters including the philosopher Zubiri and the Mayor of Madrid Enrique Tierno Galván are known to have frequented this establishment. The eagle on the façade watches over the entrance to this unique locale, with its long counter and walls lined with glass and wooden shelves.